One-pot Synthesis of Spiropyrroloquinoline-isoindolinone and Their Aza-analogs Via the Ugi-4CR/metal-free Intramolecular Bis-annulation Process

This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.