Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma: The Role of Metapneumovirus, Bocavirus and Influenza Virus

Overview

Journal Immunol Allergy Clin North Am

Specialty Allergy & Immunology

Date 2019 Jul 10

PMID 31284928

Citations 24

Authors

Andrea M Coverstone

Leyao Wang

Kaharu Sumino

Affiliations

Soon will be listed here.

Abstract

Respiratory viruses other than rhinovirus or respiratory syncytial virus, including human metapneumovirus, influenza virus, and human bocavirus, are important pathogens in acute wheezing illness and asthma exacerbations in young children. Whether infection with these viruses in early life is associated with recurrent wheezing and/or asthma is not fully investigated, although there are data to suggest children with human metapneumovirus lower respiratory tract infection may have a higher likelihood of subsequent and recurrent wheezing several years after initial infection.

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References

Turunen R, Koistinen A, Vuorinen T, Arku B, Soderlund-Venermo M, Ruuskanen O . The first wheezing episode: respiratory virus etiology, atopic characteristics, and illness severity. Pediatr Allergy Immunol. 2014; 25(8):796-803. PMC: 7167827. DOI: 10.1111/pai.12318. View

An S, Jeon Y, Jo A, Lim H, Han Y, Cho S . Initial Influenza Virus Replication Can Be Limited in Allergic Asthma Through Rapid Induction of Type III Interferons in Respiratory Epithelium. Front Immunol. 2018; 9:986. PMC: 5966536. DOI: 10.3389/fimmu.2018.00986. View

Allander T, Jartti T, Gupta S, Niesters H, Lehtinen P, Osterback R . Human bocavirus and acute wheezing in children. Clin Infect Dis. 2007; 44(7):904-10. PMC: 7107819. DOI: 10.1086/512196. View

Bonnelykke K, Vissing N, Sevelsted A, Johnston S, Bisgaard H . Association between respiratory infections in early life and later asthma is independent of virus type. J Allergy Clin Immunol. 2015; 136(1):81-86.e4. PMC: 7112259. DOI: 10.1016/j.jaci.2015.02.024. View

Cullen G, Martin J, ODonnell J, Boland M, Canny M, Keane E . Surveillance of the first 205 confirmed hospitalised cases of pandemic H1N1 influenza in Ireland, 28 April - 3 October 2009. Euro Surveill. 2009; 14(44). View

van den Hoogen B, de Jong J, Groen J, Kuiken T, de Groot R, Fouchier R . A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001; 7(6):719-24. PMC: 7095854. DOI: 10.1038/89098. View

Cates C, Rowe B . Vaccines for preventing influenza in people with asthma. Cochrane Database Syst Rev. 2013; (2):CD000364. PMC: 6999427. DOI: 10.1002/14651858.CD000364.pub4. View

Bueving H, Bernsen R, de Jongste J, van Suijlekom-Smit L, Rimmelzwaan G, Osterhaus A . Does influenza vaccination exacerbate asthma in children?. Vaccine. 2004; 23(1):91-6. DOI: 10.1016/j.vaccine.2004.03.067. View

Olenec J, Kim W, Lee W, Vang F, Pappas T, Salazar L . Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol. 2010; 125(5):1001-1006.e1. PMC: 2866802. DOI: 10.1016/j.jaci.2010.01.059. View

10.

Martin E, Kuypers J, McRoberts J, Englund J, Zerr D . Human Bocavirus 1 Primary Infection and Shedding in Infants. J Infect Dis. 2015; 212(4):516-24. PMC: 4539892. DOI: 10.1093/infdis/jiv044. View

11.

Christensen A, Nordbo S, Krokstad S, Rognlien A, Dollner H . Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection. J Clin Virol. 2010; 49(3):158-62. PMC: 7108378. DOI: 10.1016/j.jcv.2010.07.016. View

12.

Myles P, Semple M, Lim W, Openshaw P, Gadd E, Read R . Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK. Thorax. 2012; 67(8):709-17. PMC: 3402749. DOI: 10.1136/thoraxjnl-2011-200266. View

13.

Sykes A, Macintyre J, Edwards M, Del Rosario A, Haas J, Gielen V . Rhinovirus-induced interferon production is not deficient in well controlled asthma. Thorax. 2013; 69(3):240-6. DOI: 10.1136/thoraxjnl-2012-202909. View

14.

Wei H, Tsao K, Huang C, Huang Y, Lin T . Clinical features of different genotypes/genogroups of human metapneumovirus in hospitalized children. J Microbiol Immunol Infect. 2012; 46(5):352-7. DOI: 10.1016/j.jmii.2012.07.007. View

15.

Chang Y, Kim H, Albacker L, Baumgarth N, McKenzie A, Smith D . Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol. 2011; 12(7):631-8. PMC: 3417123. DOI: 10.1038/ni.2045. View

16.

Kusel M, de Klerk N, Kebadze T, Vohma V, Holt P, Johnston S . Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007; 119(5):1105-10. PMC: 7125611. DOI: 10.1016/j.jaci.2006.12.669. View

17.

Allander T, Tammi M, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B . Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A. 2005; 102(36):12891-6. PMC: 1200281. DOI: 10.1073/pnas.0504666102. View

18.

Broughton S, Sylvester K, Fox G, Zuckerman M, Smith M, Milner A . Lung function in prematurely born infants after viral lower respiratory tract infections. Pediatr Infect Dis J. 2007; 26(11):1019-24. DOI: 10.1097/INF.0b013e318126bbb9. View

19.

Khetsuriani N, Kazerouni N, Erdman D, Lu X, Redd S, Anderson L . Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol. 2006; 119(2):314-21. PMC: 7112359. DOI: 10.1016/j.jaci.2006.08.041. View

20.

Anderson H, Lemanske Jr R, Evans M, Gangnon R, Pappas T, Grindle K . Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk. J Allergy Clin Immunol. 2016; 139(2):692-694. PMC: 5026309. DOI: 10.1016/j.jaci.2016.07.031. View