Does Influenza Vaccination Exacerbate Asthma in Children?

Overview

Journal Vaccine

Specialty Allergy & Immunology

Date 2004 Nov 3

PMID 15519712

Citations 6

Authors

Herman J Bueving

Roos M D Bernsen

Johan C de Jongste

Lisette W A van Suijlekom-Smit

Guus F Rimmelzwaan

Albert D M E Osterhaus

Maureen P M H Rutten-van Molken

Siep Thomas

Johannes C van der Wouden

Affiliations

Soon will be listed here.

Abstract

Background: The risks of influenza vaccination in asthmatic children are still being discussed. Especially, the risk that influenza vaccination may exacerbate asthma is an issue in this debate.

Methods: We conducted a randomised double-blind placebo-controlled trial in 696 children 6-18 years of age with asthma recruited in general practice during two influenza seasons, 1999-2000 and 2000-2001. Children participated for only one season. During the first week after vaccination, participants recorded local, influenza like and asthma symptoms as well as use of medication, health care use and absenteeism.

Results: Except for cough during the day in the first season, favouring placebo, there were no differences indicating that vaccination exacerbates asthma.

Conclusions: Influenza vaccination does not seem to exacerbate asthma.

Citing Articles

Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma: The Role of Metapneumovirus, Bocavirus and Influenza Virus.

Coverstone A, Wang L, Sumino K Immunol Allergy Clin North Am. 2019; 39(3):391-401.

PMID: 31284928 PMC: 7127190. DOI: 10.1016/j.iac.2019.03.007.

Temporal and spatial associations between influenza and asthma hospitalisations in New York City from 2002 to 2012: a longitudinal ecological study.

Trinh P, Jung T, Keene D, Demmer R, Perzanowski M, Lovasi G BMJ Open. 2018; 8(9):e020362.

PMID: 30269061 PMC: 6169763. DOI: 10.1136/bmjopen-2017-020362.

Vaccines for preventing influenza in people with asthma.

Cates C, Rowe B Cochrane Database Syst Rev. 2013; (2):CD000364.

PMID: 23450529 PMC: 6999427. DOI: 10.1002/14651858.CD000364.pub4.

Central European Vaccination Advisory Group (CEVAG) guidance statement on recommendations for influenza vaccination in children.

Usonis V, Anca I, Andre F, Chlibek R, Ivaskeviciene I, Mangarov A BMC Infect Dis. 2010; 10:168.

PMID: 20546586 PMC: 2905419. DOI: 10.1186/1471-2334-10-168.

Confronting potential influenza A (H5N1) pandemic with better vaccines.

Haque A, Hober D, Kasper L Emerg Infect Dis. 2008; 13(10):1512-8.

PMID: 18258000 PMC: 2851514. DOI: 10.3201/eid1310.061262.