An Overview of Asthma and COVID-19: Protective Factors Against SARS-COV-2 in Pediatric Patients

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2021 May 17

PMID 33996694

Citations 12

Authors

Maria Liuzzo Scorpo

Giuliana Ferrante

Stefania La Grutta

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by severe acute respiratory syndrome coronavirus SARS-COV-2. Aberrant innate immunity response and cytokine storm are responsible for the syndrome. Apparently, in asthmatic patients, the inadequate antiviral immune response and the tendency for asthma exacerbation evoked by common respiratory viruses could explain increased susceptibility to SARS-COV-2 infection. However, asthma has not been suggested to be a risk factor in COVID-19 patients. Therefore, in asthmatic patients some potential protective mechanisms against SARS-COV-2 have been hypothesized, like type 2 immune response, number of eosinophils, overproduction of mucus, and asthma treatment, along with behavioral factors not strictly related to asthma, such as social distancing, hygiene measures and wearing facemasks, that contribute to reduce the individual susceptibility to SARS-COV-2 infection. In this mini-review, we will describe the current literature regarding potential protective factors against COVID-19 in children with asthma based on the evidence available so far.

Citing Articles

Retrospective Study of the Impact of SARS-CoV-2 Infection on Asthma Control in Children.

Abdul-Razzak J, Ionescu M, Diaconu R, Popescu A, Niculescu E, Gafencu M J Clin Med. 2025; 14(2).

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Key Characteristics of Asthma Patients with COVID-19 Vary Substantially by Age.

Kirui B, Santosa A, Li H, Vanfleteren L, Stridsman C, Nyberg F J Asthma Allergy. 2024; 17:589-600.

PMID: 38932752 PMC: 11203787. DOI: 10.2147/JAA.S456145.

The acute care burden of asthma in children was profoundly reduced during the COVID-19 pandemic: A multi-centre Canadian retrospective study.

McConnery J, Bone J, Goldman R, Hicks A, Seaton C, Subbarao P Paediatr Child Health. 2024; 29(2):98-103.

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Spatial Survival Model for COVID-19 in México.

Perez-Castro E, Guzman-Martinez M, Godinez-Jaimes F, Reyes-Carreto R, Vargas-De-Leon C, Aguirre-Salado A Healthcare (Basel). 2024; 12(3).

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Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis.

Nouri H, Schaunaman N, Kraft M, Li L, Numata M, Chu H Front Immunol. 2023; 14:1304758.

PMID: 38124753 PMC: 10731025. DOI: 10.3389/fimmu.2023.1304758.

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