Plasmid-mediated Sulfonamide Resistance in Neisseria Meningitidis

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1987 Oct 1

PMID 3124735

Citations 6

Authors

B Facinelli

P E Varaldo

Affiliations

Soon will be listed here.

Abstract

An 8.5-megadalton plasmid coding for sulfonamide resistance was found in a clinical isolate of Neisseria meningitidis, as demonstrated by plasmid elimination and transformation experiments. The plasmid complemented a mutation which determines the production of a thermosensitive dihydropteroate synthetase in Escherichia coli, thus suggesting that the mechanism of resistance involved a plasmid-encoded dihydropteroate synthetase.

Citing Articles

Multiple origins and replication proteins influence biological properties of beta-lactamase-producing plasmids from Neisseria gonorrhoeae.

Pagotto F, Dillon J J Bacteriol. 2001; 183(19):5472-81.

PMID: 11544207 PMC: 95436. DOI: 10.1128/JB.183.19.5472-5481.2001.

Plasmid carriage and antibiotic susceptibility of Neisseria meningitidis strains isolated in Sweden 1981-1990.

Backmann A, Danielsson D, Olcen P Eur J Clin Microbiol Infect Dis. 1993; 12(9):683-9.

PMID: 8243484 DOI: 10.1007/BF02009380.

Transfer of beta-lactamase plasmids from Neisseria gonorrhoeae to Neisseria meningitidis and commensal Neisseria species by the 25.2-megadalton conjugative plasmid.

Roberts M, Knapp J Antimicrob Agents Chemother. 1988; 32(9):1430-2.

PMID: 3143304 PMC: 175882. DOI: 10.1128/AAC.32.9.1430.

Plasmids of Neisseria gonorrhoeae and other Neisseria species.

Roberts M Clin Microbiol Rev. 1989; 2 Suppl:S18-23.

PMID: 2497958 PMC: 358072. DOI: 10.1128/CMR.2.Suppl.S18.

Cloning and characterization of a DNA fragment that confers sulfonamide resistance in a serogroup B, serotype 15 strain of Neisseria meningitidis.

Kristiansen B, Radstrom P, Jenkins A, Ask E, Facinelli B, SKOLD O Antimicrob Agents Chemother. 1990; 34(11):2277-9.

PMID: 2127350 PMC: 172039. DOI: 10.1128/AAC.34.11.2277.

References

Mandel M, Higa A . Calcium-dependent bacteriophage DNA infection. J Mol Biol. 1970; 53(1):159-62. DOI: 10.1016/0022-2836(70)90051-3. View

Facinelli B, Montanari M, Piermattei P . Plasmid deoxyribonucleic acid in throat and cerebrospinal fluid isolates of Neisseria meningitidis. Eur J Epidemiol. 1987; 3(2):206-8. DOI: 10.1007/BF00239761. View

Sox T, Mohammed W, Sparling P . Transformation-derived Neisseria gonorrhoeae plasmids with altered structure and function. J Bacteriol. 1979; 138(2):510-8. PMC: 218206. DOI: 10.1128/jb.138.2.510-518.1979. View

Verschueren H, Dekegel M, Dekegel D, Gilquin C, de Mayer S . Plasmids in Neisseria meningitidis. Lancet. 1982; 1(8276):851-2. DOI: 10.1016/s0140-6736(82)91896-7. View

Albritton W, Brunton J, Slaney L, Maclean I . Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi. Antimicrob Agents Chemother. 1982; 21(1):159-65. PMC: 181845. DOI: 10.1128/AAC.21.1.159. View

Dillon J, Pauze M, Yeung K . Spread of penicillinase-producing and transfer plasmids from the gonococcus to Neisseria meningitidis. Lancet. 1983; 1(8328):779-81. DOI: 10.1016/s0140-6736(83)91846-9. View

Band J, Chamberland M, Platt T, Weaver R, Thornsberry C, Fraser D . Trends in meningococcal disease in the United States, 1975-1980. J Infect Dis. 1983; 148(4):754-8. DOI: 10.1093/infdis/148.4.754. View

Foster T . Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria. Microbiol Rev. 1983; 47(3):361-409. PMC: 281581. DOI: 10.1128/mr.47.3.361-409.1983. View

Ison C, Bellinger C, GLYNN A . Plasmids in throat and genital isolates of meningococci. J Clin Pathol. 1984; 37(10):1123-8. PMC: 498952. DOI: 10.1136/jcp.37.10.1123. View

10.

Kieser T . Factors affecting the isolation of CCC DNA from Streptomyces lividans and Escherichia coli. Plasmid. 1984; 12(1):19-36. DOI: 10.1016/0147-619x(84)90063-5. View

11.

Pintado C, Salvador C, Rotger R, Nombela C . Multiresistance plasmid from commensal Neisseria strains. Antimicrob Agents Chemother. 1985; 27(1):120-4. PMC: 176216. DOI: 10.1128/AAC.27.1.120. View

12.

Saunders J . Genetics and evolution of antibiotic resistance. Br Med Bull. 1984; 40(1):54-60. DOI: 10.1093/oxfordjournals.bmb.a071948. View

13.

Prere M, Fayet O, Delmas C, LARENG M, Dabernat H . [Presence of plasmids in Neisseria meningitidis]. Ann Inst Pasteur Microbiol (1985). 1985; 136A(2):271-6. DOI: 10.1016/s0769-2609(85)80066-1. View

14.

Feldman H . The meningococcus: a twenty-year perspective. Rev Infect Dis. 1986; 8(2):288-94. DOI: 10.1093/clinids/8.2.288. View

15.

Brunton J, Clare D, Meier M . Molecular epidemiology of antibiotic resistance plasmids of Haemophilus species and Neisseria gonorrhoeae. Rev Infect Dis. 1986; 8(5):713-24. DOI: 10.1093/clinids/8.5.713. View

16.

SKOLD O . R-factor-mediated resistance to sulfonamides by a plasmid-borne, drug-resistant dihydropteroate synthase. Antimicrob Agents Chemother. 1976; 9(1):49-54. PMC: 429472. DOI: 10.1128/AAC.9.1.49. View