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Cloning and Characterization of a DNA Fragment That Confers Sulfonamide Resistance in a Serogroup B, Serotype 15 Strain of Neisseria Meningitidis

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1990 Nov 1
PMID 2127350
Citations 14
Authors
B E Kristiansen
P Radstrom
A Jenkins
E Ask
B Facinelli
O SKOLD
Affiliations
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Abstract

By cloning studies and complementation experiments, the sulfonamide resistance gene of a serogroup B and serotype 15 (B:15) strain of Neisseria meningitidis was localized to a 1.2-kb chromosomal SspI fragment expressing a drug-resistant dihydropteroate synthase. The fragment hybridized to DNA from both resistant and susceptible strains, suggesting that the resistance gene is a variant of the normal gene for dihydropteroate synthase.

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Variations in gene organization and DNA uptake signal sequence in the folP region between commensal and pathogenic Neisseria species.

Qvarnstrom Y, Swedberg G BMC Microbiol. 2006; 6:11.

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References
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