Recent Advances in Droplet-based Microfluidic Technologies for Biochemistry and Molecular Biology

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2019 Jun 23

PMID 31226819

Citations 24

Authors

Joel Sanchez Barea

Juhwa Lee

Dong-Ku Kang

Affiliations

Soon will be listed here.

Abstract

Recently, droplet-based microfluidic systems have been widely used in various biochemical and molecular biological assays. Since this platform technique allows manipulation of large amounts of data and also provides absolute accuracy in comparison to conventional bioanalytical approaches, over the last decade a range of basic biochemical and molecular biological operations have been transferred to drop-based microfluidic formats. In this review, we introduce recent advances and examples of droplet-based microfluidic techniques that have been applied in biochemistry and molecular biology research including genomics, proteomics and cellomics. Their advantages and weaknesses in various applications are also comprehensively discussed here. The purpose of this review is to provide a new point of view and current status in droplet-based microfluidics to biochemists and molecular biologists. We hope that this review will accelerate communications between researchers who are working in droplet-based microfluidics, biochemistry and molecular biology.

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