HJURP Promotes Epithelial-to-Mesenchymal Transition Via Upregulating SPHK1 in Hepatocellular Carcinoma

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2019 Jun 22

PMID 31223275

Citations 15

Authors

Tianchi Chen

Lingfeng Zhou

Yuan Zhou

Wuhua Zhou

Hechen Huang

Shengyong Yin

Haiyang Xie

Lin Zhou

Shusen Zheng

Affiliations

Soon will be listed here.

Abstract

Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, we found that HJURP knockdown significantly reduced the migration and invasion abilities of HCC cells both and by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients.

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