Complex Networks Orchestrate Epithelial-mesenchymal Transitions

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2006 Feb 24

PMID 16493418

Citations 1922

Authors

Jean Paul Thiery

Jonathan P Sleeman

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

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