Revisiting Gametocyte Biology in Malaria Parasites

Overview

Journal FEMS Microbiol Rev

Publisher Oxford University Press

Specialty Microbiology

Date 2019 Jun 21

PMID 31220244

Citations 49

Authors

Priscilla Ngotho

Alexandra Blancke Soares

Franziska Hentzschel

Fiona Achcar

Lucia Bertuccini

Matthias Marti

Affiliations

Soon will be listed here.

Abstract

Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed focus on malaria transmission biology as a basis for interventions. This review discusses recent insights into gametocyte biology in the major human malaria parasite, Plasmodium falciparum and related species.

Citing Articles

Comparative 3D ultrastructure of Plasmodium falciparum gametocytes.

Evers F, Roverts R, Boshoven C, Kea-Te Lindert M, Verhoef J, Sommerdijk N Nat Commun. 2025; 16(1):69.

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Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials.

Naude M, van Heerden A, Reader J, van der Watt M, Niemand J, Joubert D Nat Commun. 2024; 15(1):9896.

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Heterochromatin dynamics during the initial stages of sexual development in Plasmodium falciparum.

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The three Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual blood stage parasites and gametocytes.

Wyss M, Thommen B, Kofler J, Carrington E, Brancucci N, Voss T mSphere. 2024; 9(9):e0046524.

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Plant-based nanoparticles targeting malaria management.

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