Blood Microbial Communities During Pregnancy Are Associated With Preterm Birth

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2019 Jun 20

PMID 31214131

Citations 17

Authors

Young-Ah You

Jae Young Yoo

Eun Jin Kwon

Young Ju Kim

Affiliations

Soon will be listed here.

Abstract

Microbial infection of the placenta, amniotic fluid, vaginal canal, and oral cavity is known to significantly contribute to preterm birth (PTB). Although microbes can be translocated into the blood, little is known regarding the blood microbiota during pregnancy. To assess changes in the microbiome during pregnancy, blood samples were obtained 2 or 3 times during pregnancy from a cohort of 45 pregnant women enrolled between 2008 and 2010. To analyze the association with PTB, we conducted a case-control study involving 41 pregnant women upon admission for preterm labor and rupture of membrane (20 with term delivery; 21 with PTB). Bacterial diversity was assessed in number and composition between the first, second, and third trimesters in term delivered women according to 16S rRNA gene amplicon sequencing, and data were analyzed using Quantitative Insight Into Microbial Ecology (QIIME). Taxonomy was assigned using the GreenGenes 8.15.13 database. Dominant microorganisms at the phylum level in all pregnant women were identified as , , , and . However, the number and composition of bacteria in women with PTB differed from that in women with term delivery. and were more abundant in women with PTB than in women with term delivery, while was less prevalent in women with PTB. At the genus level, , , , , , and were enriched in PTB samples. These observational results suggest that several taxa in the maternal blood microbiome are associated with PTB. Further studies are needed to confirm the composition of the blood microbiota in women with PTB. Additionally, the mechanism by which pathogenic microbes in maternal blood cause infection and PTB requires further analysis.

Citing Articles

Maternal and infant microbiome and birth anthropometry.

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A Case of Sepsis in Which Escherichia coli and Fastidiosipila sanguinis Were Isolated and Identified From a Blood Culture.

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Dysbiotic Vaginal Microbiota Induces Preterm Birth Cascade via Pathogenic Molecules in the Vagina.

Ansari A, You Y, Lee G, Kim S, Park S, Hur Y Metabolites. 2024; 14(1).

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Oral microbiome and preterm birth.

Vidmar Simic M, Maver A, Zimani A, Hocevar K, Peterlin B, Kovanda A Front Med (Lausanne). 2023; 10:1177990.

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