Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2019 Jun 18

PMID 31204101

Citations 72

Authors

David R Martinez

Youyi Fong

Shuk Hang Li

Fang Yang

Madeleine F Jennewein

Joshua A Weiner

Erin A Harrell

Jesse F Mangold

Ria Goswami

George R Seage 3rd

Galit Alter

Margaret E Ackerman

Xinxia Peng

Genevieve G Fouda

Sallie R Permar

Affiliations

Soon will be listed here.

Abstract

The placental transfer of maternal IgG is critical for infant protection against infectious pathogens. However, factors that modulate the placental transfer of IgG remain largely undefined. HIV-infected women have impaired placental IgG transfer, presenting a unique "disruption model" to define factors that modulate placental IgG transfer. We measured the placental transfer efficiency of maternal HIV and pathogen-specific IgG in US and Malawian HIV-infected mothers and their HIV-exposed uninfected and infected infants. We examined the role of maternal HIV disease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatures and their association with placental IgG transfer efficiency. Maternal IgG characteristics, such as binding to placentally expressed Fc receptors FcγRIIa and FcγRIIIa, and Fc region glycan profiles were associated with placental IgG transfer efficiency. Our findings suggest that Fc region characteristics modulate the selective placental transfer of IgG, with implications for maternal vaccine design and infant health.

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