Gut-X Axis

Overview

Journal Imeta

Specialty Biology

Date 2025 Mar 3

PMID 40027477

Authors

Xu Lin

Zuxiang Yu

Yang Liu

Changzhou Li

Hui Hu

Jia-Chun Hu

Mian Liu

Qin Yang

Peng Gu

Jiaxin Li

Kutty Selva Nandakumar

Gaofei Hu

Qi Zhang

Xinyu Chen

Huihui Ma

Wenye Huang

Gaofeng Wang

Yan Wang

Liping Huang

Wenjuan Wu

Ning-Ning Liu

Chenhong Zhang

Xingyin Liu

Leming Zheng

Peng Chen

Affiliations

Soon will be listed here.

Abstract

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the "gut-X axis" concept to describe the linkages between the gut and other organs and discussed the latest findings related to the "gut-X axis," including the underlying modulatory mechanisms and potential clinical intervention strategies.

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