Sperm Success and Immunity

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2019 Jun 4

PMID 31155361

Citations 32

Authors

Stuart Wigby

Susan S Suarez

Brian P Lazzaro

Tommaso Pizzari

Mariana F Wolfner

Affiliations

Soon will be listed here.

Abstract

The moment of the fertilization of an egg by a spermatozoon-the point of "sperm success"-is a key milestone in the biology of sexually reproducing species and is a fundamental requirement for offspring production. Fertilization also represents the culmination of a suite of sexually selected processes in both sexes and is commonly used as a landmark to measure reproductive success. Sperm success is heavily dependent upon interactions with other key aspects of male and female biology, with the immune system among the most important. The immune system is vital to maintaining health in both sexes; however, immune reactions can also have antagonistic effects on sperm success. The effects of immunity on sperm success are diverse, and may include trade-offs in the male between investment in the production or protection of sperm, as well as more direct, hostile, immune responses to sperm within the female, and potentially the male, reproductive tract. Here, we review current understanding of where the biology of immunity and sperm meet, and identify the gaps in our knowledge.

Citing Articles

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Identification of Estrogen-Responsive Proteins in Mouse Seminal Vesicles Through Mass Spectrometry-Based Proteomics.

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What proteomics has taught us about honey bee (Apis mellifera) health and disease.

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Anti-sperm Antibodies as an Increasing Threat to Male Fertility: Immunological Insights, Diagnostic and Therapeutic Strategies.

Mukherjee A, Gopalakrishnan A Reprod Sci. 2024; 31(11):3303-3322.

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Bovine reproductive immunoinfertility: pathogenesis and immunotherapy.

Gupta V, Mohanty T, Bhakat M, Dewry R, Katiyar R, Nain D Front Vet Sci. 2023; 10:1248604.

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