Prognostic Value of Tumor-infiltrating Lymphocytes in Melanoma: a Systematic Review and Meta-analysis

Overview

Journal Oncoimmunology

Specialty Allergy & Immunology

Date 2019 May 31

PMID 31143514

Citations 129

Authors

Qiaofen Fu

Nan Chen

Chunlei Ge

Ruilei Li

Zhen Li

Baozhen Zeng

Chunyan Li

Ying Wang

YuanBo Xue

Xin Song

Heng Li

Gaofeng Li

Affiliations

Soon will be listed here.

Abstract

Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILs present and improved overall survival. Additionally, subgroup analysis demonstrated that brisk TILs were obviously associated with OS, RFS and DSS/MSS. Thus, TILs may be a predictive biomarker in melanoma. This analysis will provide more insight into the study of TILs and predictive biomarker.

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