» Articles » PMID: 18510923

Regulatory T Cells and Immune Tolerance

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2008 May 31
PMID 18510923
Citations 2386
Authors
Affiliations
Soon will be listed here.
Abstract

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

Citing Articles

Could immunotherapy and regulatory T cells be used therapeutically to slow the progression of Alzheimer's disease?.

Abbott V, Housden B, Houldsworth A Brain Commun. 2025; 7(2):fcaf092.

PMID: 40078868 PMC: 11896979. DOI: 10.1093/braincomms/fcaf092.


Engineered extracellular vesicles promote the repair of acute kidney injury by modulating regulatory T cells and the immune microenvironment.

Xie L, Zhang K, Pan K, Su X, Zhao X, Li R J Transl Med. 2025; 23(1):304.

PMID: 40065372 PMC: 11895318. DOI: 10.1186/s12967-025-06268-x.


Deubiquitinases and Cancer.

Murali P, Kavitha B, Narasimhan M J Pharm Bioallied Sci. 2025; 16(Suppl 5):S4210-S4220.

PMID: 40061651 PMC: 11888656. DOI: 10.4103/jpbs.jpbs_517_24.


Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia.

Joudi A, Gurkan J, Liu Q, Acosta M, Helmin K, Morales-Nebreda L bioRxiv. 2025; .

PMID: 40060513 PMC: 11888461. DOI: 10.1101/2025.02.25.640199.


Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells.

Zhang H, Podesta M, Cavazzoni C, Wu Y, Lee J, Li X Nat Commun. 2025; 16(1):2151.

PMID: 40038336 PMC: 11880397. DOI: 10.1038/s41467-025-57468-4.