Biological Effects of Food Coloring in In Vivo and In Vitro Model Systems

Overview

Journal Foods

Specialty Biotechnology

Date 2019 May 30

PMID 31137639

Citations 15

Authors

Rocio Merinas-Amo

Maria Martinez-Jurado

Silvia Jurado-Gueto

Angeles Alonso-Moraga

Tania Merinas-Amo

Affiliations

Soon will be listed here.

Abstract

(1) Background: The suitability of certain food colorings is nowadays in discussion because of the effects of these compounds on human health. For this reason, in the present work, the biological effects of six worldwide used food colorings (Riboflavin, Tartrazine, Carminic Acid, Erythrosine, Indigotine, and Brilliant Blue FCF) were analyzed using two model systems. (2) Methods: In vivo toxicity, antitoxicity, and longevity assays using the model organism and in vitro cytotoxicity, DNA fragmentation, and methylation status assays using HL-60 tumor human cell line were carried out. (3) Results: Our in vivo results showed safe effects in for all the food coloring treatments, non-significant protective potential against an oxidative toxin, and different effects on the lifespan of flies. The in vitro results in HL-60 cells, showed that the tested food colorings increased tumor cell growth but did not induce any DNA damage or modifications in the DNA methylation status at their acceptable daily intake (ADI) concentrations. (4) Conclusions: From the in vivo and in vitro studies, these results would support the idea that a high chronic intake of food colorings throughout the entire life is not advisable.

Citing Articles

Safety of tartrazine in the food industry and potential protective factors.

Amchova P, Siska F, Ruda-Kucerova J Heliyon. 2024; 10(18):e38111.

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Assessment of synthetic food dye erythrosine induced cytotoxicity, genotoxicity, biochemical and molecular alterations in root meristematic cells: insights from in silico study.

Singh M, Chadha P Toxicol Res (Camb). 2024; 13(4):tfae126.

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Food Safety and Health Concerns of Synthetic Food Colors: An Update.

Amchova P, Siska F, Ruda-Kucerova J Toxics. 2024; 12(7).

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Indigo Carmine: Between Necessity and Concern.

Ristea M, Zarnescu O J Xenobiot. 2023; 13(3):509-528.

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Tartrazine Modifies the Activity of and Genes-Is This a Link between Cancer and Neurological Disorders?.

Zand A, Enkhbilguun S, Macharia J, Budan F, Gyongyi Z, Varjas T Nutrients. 2023; 15(13).

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