Peripheral Blood Stem Cell Mobilization; a Look Ahead

Overview

Journal Curr Stem Cell Rep

Date 2019 May 28

PMID 31131207

Citations 22

Authors

Louis M Pelus

Hal E Broxmeyer

Affiliations

Soon will be listed here.

Abstract

The Purpose Of Review: Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to recapitulate lifelong hematopoiesis, but in some patients and normal donors, reaching critical threshold stem cell numbers are difficult to achieve. Novel strategies, particularly those offering rapid mobilization and reduced costs, remains an area of interest.This review summarizes critical scientific underpinnings in understanding the process of stem cell mobilization, with a focus on new or improved strategies for their efficient collection and engraftment.

Recent Findings: Studies are described that provide new insights into the complexity of stem cell mobilization. Agents that target new pathways such HSC egress, identify strategies to collect more potent competing HSC and new methods to optimize stem cell collection and engraftment are being evaluated.

Summary: Agents and more effective strategies that directly address the current shortcomings of hematopoietic stem cell mobilization and transplantation and offer the potential to facilitate collection and expand use of mobilized stem cells have been identified.

Citing Articles

Molecular gene signature of circulating stromal/stem cells.

Lin W, Xu L, Li G, Tortorella M J Hum Genet. 2025; .

PMID: 40069498 DOI: 10.1038/s10038-025-01322-4.

The Different Responsiveness of C3- and C5-deficient Murine BM Cells to Oxidative Stress Explains Why C3 Deficiency, in Contrast to C5 Deficiency, Correlates with Better Pharmacological Mobilization and Engraftment of Hematopoietic Cells.

Konopko A, Lukomska A, Kucia M, Ratajczak M Stem Cell Rev Rep. 2024; 21(1):59-67.

PMID: 39340736 PMC: 11762589. DOI: 10.1007/s12015-024-10792-6.

Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells.

Guo B, Huang X, Chen Y, Broxmeyer H Adv Exp Med Biol. 2024; 1442:85-104.

PMID: 38228960 DOI: 10.1007/978-981-99-7471-9_6.

The quest for the holy grail: overcoming challenges in expanding human hematopoietic stem cells for clinical use.

Bastani S, Staal F, Cante-Barrett K Stem Cell Investig. 2023; 10:15.

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Harvest Quality, Nucleated Cell Dose and Clinical Outcomes in Bone Marrow Transplantation: A Retrospective Study.

Mamo T, Sumstad D, DeFor T, Cao Q, MacMillan M, Brunstein C Transplant Cell Ther. 2023; 29(10):638.e1-638.e8.

PMID: 37419326 PMC: 10592389. DOI: 10.1016/j.jtct.2023.07.003.

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