Association Between the Rs2288947 Polymorphism of the LncRNA TINCR Gene and the Risk of Recurrent Miscarriage in a Southern Chinese Population

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2019 May 25

PMID 31124188

Citations 5

Authors

Wendong Huang

Huazhong Zhou

Lei Pi

Yufen Xu

Lanyan Fu

Yanfang Yang

Di Che

Xiaoqiong Gu

Affiliations

Soon will be listed here.

Abstract

Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation-induced non-coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various diseases. However, whether the lncRNA TINCR polymorphism is associated with susceptibility to recurrent miscarriage is unclear. Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647-1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475-1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653-1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505-1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. A larger multicenter study is needed to confirm our conclusions.

Citing Articles

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Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population.

Huang W, Zhou H, Pi L, Xu Y, Fu L, Yang Y J Clin Lab Anal. 2019; 33(6):e22919.

PMID: 31124188 PMC: 6642304. DOI: 10.1002/jcla.22919.

References

Xu T, Wang Y, Xiong W, Ma P, Wang W, Chen W . E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis. Cell Death Dis. 2017; 8(6):e2837. PMC: 5520882. DOI: 10.1038/cddis.2017.205. View

Kretz M, Siprashvili Z, Chu C, Webster D, Zehnder A, Qu K . Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature. 2012; 493(7431):231-5. PMC: 3674581. DOI: 10.1038/nature11661. View

Liu Y, Du Y, Hu X, Zhao L, Xia W . Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer. BMC Cancer. 2018; 18(1):367. PMC: 5883880. DOI: 10.1186/s12885-018-4255-3. View

Kretz M . TINCR, staufen1, and cellular differentiation. RNA Biol. 2013; 10(10):1597-601. PMC: 3866239. DOI: 10.4161/rna.26249. View

Xu T, Liu X, Xia R, Yin L, Kong R, Chen W . SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer. Oncogene. 2015; 34(45):5648-61. DOI: 10.1038/onc.2015.18. View

Tian F, Xu J, Xue F, Guan E, Xu X . TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma. Biosci Rep. 2017; 37(4). PMC: 5529205. DOI: 10.1042/BSR20170301. View

Huang W, Zhou H, Pi L, Xu Y, Fu L, Yang Y . Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population. J Clin Lab Anal. 2019; 33(6):e22919. PMC: 6642304. DOI: 10.1002/jcla.22919. View

Dong L, Ding H, Li Y, Xue D, Liu Y . LncRNA TINCR is associated with clinical progression and serves as tumor suppressive role in prostate cancer. Cancer Manag Res. 2018; 10:2799-2807. PMC: 6108330. DOI: 10.2147/CMAR.S170526. View

Wang H, Cao Q, Ge J, Liu C, Ma Y, Meng Y . LncRNA-regulated infection and inflammation pathways associated with pregnancy loss: genome wide differential expression of lncRNAs in early spontaneous abortion. Am J Reprod Immunol. 2014; 72(4):359-75. DOI: 10.1111/aji.12275. View

10.

Li L, Liu J, Qin S, Li R . Correlation between CTLA4 genetic polymorphisms, its serum protein level and the susceptibility to recurrent spontaneous abortion: A case-control study. Medicine (Baltimore). 2018; 97(42):e12754. PMC: 6211885. DOI: 10.1097/MD.0000000000012754. View

11.

Liu X, Ma J, Xu F, Li L . TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer. Biomed Pharmacother. 2018; 99:9-17. DOI: 10.1016/j.biopha.2018.01.049. View

12.

Zhang Y, Jin F, Li X, Shen F, Ma X, Wu F . The YY1-HOTAIR-MMP2 Signaling Axis Controls Trophoblast Invasion at the Maternal-Fetal Interface. Mol Ther. 2017; 25(10):2394-2403. PMC: 5628865. DOI: 10.1016/j.ymthe.2017.06.028. View

13.

Quintero-Ronderos P, Mercier E, Gris J, Esteban-Perez C, Moreno-Ortiz H, Fonseca D . THBD sequence variants potentially related to recurrent pregnancy loss. Reprod Biol Endocrinol. 2017; 15(1):92. PMC: 5709961. DOI: 10.1186/s12958-017-0311-0. View

14.

Zheng Y, Yang C, Tong S, Ding Y, Deng W, Song D . Genetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer. Oncotarget. 2017; 8(20):33536-33543. PMC: 5464888. DOI: 10.18632/oncotarget.16538. View

15.

Hu Y, Huo Z, Liu C, Liu S, Zhang N, Yin K . Functional study of one nucleotide mutation in pri-miR-125a coding region which related to recurrent pregnancy loss. PLoS One. 2014; 9(12):e114781. PMC: 4257728. DOI: 10.1371/journal.pone.0114781. View

16.

Ma X, Huang C, Luo D, Wang Y, Tang R, Huan X . Tag SNPs of long non-coding RNA TINCR affect the genetic susceptibility to gastric cancer in a Chinese population. Oncotarget. 2016; 7(52):87114-87123. PMC: 5349975. DOI: 10.18632/oncotarget.13513. View

17.

Feng C, Shen J, Lv P, Jin M, Wang L, Rao J . Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity. Int J Biol Sci. 2018; 14(10):1361-1377. PMC: 6097487. DOI: 10.7150/ijbs.25081. View

18.

Qiu M, Feng D, Zhang H, Xia W, Xu Y, Wang J . Comprehensive analysis of lncRNA expression profiles and identification of functional lncRNAs in lung adenocarcinoma. Oncotarget. 2016; 7(13):16012-22. PMC: 4941294. DOI: 10.18632/oncotarget.7559. View

19.

Dandan W, Jianliang C, Haiyan H, Hang M, Xuedong L . Long noncoding RNA MIR31HG is activated by SP1 and promotes cell migration and invasion by sponging miR-214 in NSCLC. Gene. 2019; 692:223-230. DOI: 10.1016/j.gene.2018.12.077. View

20.

Pereza N, Ostojic S, Kapovic M, Peterlin B . Systematic review and meta-analysis of genetic association studies in idiopathic recurrent spontaneous abortion. Fertil Steril. 2016; 107(1):150-159.e2. DOI: 10.1016/j.fertnstert.2016.10.007. View