E2F1 Induces TINCR Transcriptional Activity and Accelerates Gastric Cancer Progression Via Activation of TINCR/STAU1/CDKN2B Signaling Axis

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2017 Jun 2

PMID 28569791

Citations 68

Authors

Tong-Peng Xu

Yan-Fen Wang

Wei-Liang Xiong

Pei Ma

Wen-Yu Wang

Wen-Ming Chen

Ming-De Huang

Rui Xia

Rong Wang

Er-Bao Zhang

Yan-Wen Liu

Wei De

Yong-Qian Shu

Affiliations

Soon will be listed here.

Abstract

Recent evidence indicates that E2F1 transcription factor have pivotal roles in the regulation of cellular processes, and is found to be dysregulated in a variety of cancers. Long non-coding RNAs (lncRNAs) are also reported to exert important effect on tumorigenesis. E2F1 is aberrantly expressed in gastric cancer (GC), and biology functions of E2F1 in GC are controversial. The biological characteristics of E2F1 and correlation between E2F1 and lncRNAs in GC remain to be found. In this study, integrated analysis revealed that E2F1 expression was significantly increased in GC cases and its expression was positively correlated with the poor pathologic stage, large tumor size and poor prognosis. Forced E2F1 expression promotes proliferation, whereas loss of E2F1 function decreased cell proliferation by blocking of cell cycle in GC cells. Mechanistic analyses indicated that E2F1 accelerates GC growth partly through induces TINCR transcription. TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of GC cells. Together, our findings suggest that E2F1/TINCR/STAU1/CDKN2B signaling axis contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease.

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