Noninvasive Indicators Predict Advanced Liver Fibrosis in Autoimmune Hepatitis Patients

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2019 May 23

PMID 31115929

Citations 16

Authors

Lingyan Liu

Junying Cao

Zhengrong Zhong

Zhuying Guo

Yunfei Jiang

Yupan Bai

Jie Xu

Affiliations

Soon will be listed here.

Abstract

Background: Liver biopsy is the criterion standard for diagnosing liver fibrosis, but it is not widely used to monitor liver fibrosis because of the invasiveness, risk of complications, and sample errors. Therefore, it is necessary to involve other techniques to monitor liver fibrosis or cirrhosis during clinical practice. The objective was to explore noninvasive indicators to predict advanced liver fibrosis in autoimmune hepatitis (AIH) patients.

Methods: A total of 45 AIH patients and 47 healthy controls were recruited to this retrospective study. Complete blood count and liver function tests were performed for all subjects. AIH patients were divided into "no/minimal fibrosis" group and "advanced fibrosis" group based on liver biopsy.

Results: AIH patients demonstrated significantly higher monocytes, MCV, RDW-CV, RDW-SD, NLR, RDW-CV/PLT, RDW-SD/PLT, TBIL, DBIL, GLB, ALT, AST, GGT, ALP, and GPR and lower WBC, neutrophils, lymphocytes, RBC, HGB, HCT, LMR, TP, ALB, and AAR compared with healthy controls. Patients with advanced fibrosis showed remarkably higher RDW-CV, RDW-SD, RDW-CV/PLT, RDW-SD/PLT, AAR, and FIB-4 and lower RBC, PLT, PCT, and ALB compared with the no/minimal fibrosis group. Logistic regression analysis showed that RDW-SD/PLT was an independent risk factor for advanced fibrosis with an OR (95% CI) of 2.647 (1.383-5.170). Receiver operating characteristic (ROC) analysis revealed that RDW-SD, RDW-CV/PLT, RDW-SD/PLT, FIB-4, and AAR had an area under the ROC curve (AUC) above 0.700 and RDW-SD/PLT had the largest AUC of 0.785 with a cutoff value of 0.239.

Conclusion: RDW-SD, RDW-CV/PLT, RDW-SD/PLT, FIB-4, and AAR were excellent noninvasive biomarkers and RDW-SD/PLT was an independent risk factor for predicting advanced fibrosis in AIH patients.

Citing Articles

Diagnostic Performance of Shear-Wave Elastography in Autoimmune Hepatitis: Evaluating Baseline Characteristics and Accuracy Across Fibrosis Stages.

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Using blood routine indicators to establish a machine learning model for predicting liver fibrosis in patients with Schistosoma japonicum.

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Liver inflammation activity in patients with autoimmune hepatitis with normal alanine aminotransferase and immunoglobulin G levels.

Chen Y, Liu J, Wang J, Wu W, Wang H, Liu Y J Transl Autoimmun. 2024; 8:100220.

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Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis.

Chen H, Shen Y, Wu S, Zhu Q, Weng C, Zhang J World J Gastroenterol. 2023; 29(39):5503-5525.

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