Non-invasive Serum Fibrosis Markers: A Study in Chronic Hepatitis

Overview

Journal Bioimpacts

Specialty Biomedical Engineering

Date 2015 Apr 23

PMID 25901293

Citations 14

Authors

Mohammadreza Abdollahi

Aliasghar Pouri

Morteza Ghojazadeh

Rasoul Estakhri

Mohammadhossein Somi

Affiliations

Soon will be listed here.

Abstract

Introduction: Chronic hepatitis is specified as inflammatory disease of the liver lasting for more than six months. Role of noninvasive fibrosis markers as prognostication factors of the presence or absence of significant fibrosis on liver biopsy of patients with chronic hepatitis is the aim of this study.

Methods: Two hundred twenty-one patients with chronic hepatitis involved in the study between 2011 and 2013. Routine biochemical indices and serum fibrosis markers such as aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR), AST to platelet ratio index (APRI) and Fibrosis 4 score (FIB-4) were evaluated, and the histological grade and stage of the liver biopsy specimens were scored according to the Ishak scoring system. Diagnostic accuracies of these markers for prediction of significant fibrosis were assessed by Receiver Operating Characteristic (ROC) curve analysis.

Results: Contemporaneous laboratory indices for imputing AAR, APRI, and FIB-4 were identified with liver biopsies. From all, 135 males (61.1%) and 86 females (38.9%), with mean age of 39.6±14.4 were studied. Significant correlation between stages of fibrosis and FIB-4, APRI and AAR were detected, with a correlation coefficient higher than that of other markers in the patients with Hepatitis B (r = 0.46), C (r = 0.58) and autoimmune hepatitis (r = 0.28). FIB-4 (AUROC = 0.84) and APRI (AUROC = 0.78) were superior to AAR at distinguishing severe fibrosis from mild-to-moderate fibrosis and gave the highest diagnostic accuracy.

Conclusion: Application of these markers was good at distinguishing significant fibrosis and decreased the need for staging liver biopsy specimens among patients with chronic hepatitis.

Citing Articles

Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis.

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PMID: 37900994 PMC: 10600811. DOI: 10.3748/wjg.v29.i39.5503.

APRI and FIB-4 indices as diagnostic noninvasive scores for prediction of severe fibrosis in patients with biliary atresia.

Nagi S, Zakaria H, Elkhadry S, Hamed W, Gaballa N, Elkholy S Clin Exp Hepatol. 2023; 9(3):251-264.

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AST/ALT ratio, APRI, and FIB-4 compared to FibroScan for the assessment of liver fibrosis in patients with chronic hepatitis B in Bandar Abbas, Hormozgan, Iran.

Moosavy S, Eftekhar E, Davoodian P, Nejatizadeh A, Shadman M, Zare S BMC Gastroenterol. 2023; 23(1):145.

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Wan M, Xu H, Li D, Wang L, Li X Medicine (Baltimore). 2021; 100(6):e24723.

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