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A Study of the Prebiotic Effect of Lactulose at Low Dosages in Healthy Japanese Women

Overview
Journal Biosci Microbiota Food Health
Specialty Biology
Date 2019 May 21
PMID 31106110
Citations 9
Authors
Yohei Sakai
Nobuo Seki
Hirokazu Hamano
Hiroshi Ochi
Fumiaki Abe
Fumiko Shimizu
Kazuya Masuda
Hisakazu Iino
Affiliations
Soon will be listed here.
Abstract

To investigate the prebiotic effect of lactulose at low dosages, we assessed changes in defaecation frequency following ingestion of 1, 2, or 3 g/day of lactulose for 2 weeks. Each test was carried out after a 2-week washout period. This was an open-label, before-after trial that enrolled 26 healthy Japanese women. The defaecation frequency, number of defaecation days, and number of faecal bifidobacteria increased significantly compared with before ingestion of 1, 2, and 3 g/day of lactulose. These results suggest that even 1 g/day of lactulose could have a prebiotic effect.

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References
1.
PETUELY F . [Lactobacillus bifidus flora produced in artificially-fed infants by bifidogenic substances (bifidus factor)]. Z Kinderheilkd. 1957; 79(2):174-9. View
2.
Matsuki T, Watanabe K, Fujimoto J, Kado Y, Takada T, Matsumoto K . Quantitative PCR with 16S rRNA-gene-targeted species-specific primers for analysis of human intestinal bifidobacteria. Appl Environ Microbiol. 2004; 70(1):167-73. PMC: 321263. DOI: 10.1128/AEM.70.1.167-173.2004. View
3.
Bouhnik Y, Attar A, Joly F, Riottot M, Dyard F, Flourie B . Lactulose ingestion increases faecal bifidobacterial counts: a randomised double-blind study in healthy humans. Eur J Clin Nutr. 2004; 58(3):462-6. DOI: 10.1038/sj.ejcn.1601829. View
4.
Vanhoutte T, De Preter V, De Brandt E, Verbeke K, Swings J, Huys G . Molecular monitoring of the fecal microbiota of healthy human subjects during administration of lactulose and Saccharomyces boulardii. Appl Environ Microbiol. 2006; 72(9):5990-7. PMC: 1563651. DOI: 10.1128/AEM.00233-06. View
5.
Satoh T, Odamaki T, Namura M, Shimizu T, Iwatsuki K, Nishimoto M . In vitro comparative evaluation of the impact of lacto-N-biose I, a major building block of human milk oligosaccharides, on the fecal microbiota of infants. Anaerobe. 2012; 19:50-7. DOI: 10.1016/j.anaerobe.2012.12.007. View