Prebiotic Food Intake May Improve Bone Resorption in Japanese Female Athletes: A Pilot Study

Overview

Journal Sports (Basel)

Publisher MDPI

Specialty Public Health

Date 2021 Jul 2

PMID 34200082

Citations 1

Authors

Tatsuya Ishizu

Eri Takai

Suguru Torii

Motoko Taguchi

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to clarify the influence of inulin and lactulose-fortified prebiotic food intakes on bone metabolism turnover among Japanese female athletes. The participants included 29 female athletes aged 18-25 years. They were requested to consume their habitual foods or drinks with one pack of prebiotic food every day for 12 weeks. Dietary intake, training time, body composition, blood sample, and fecal microbiota were assessed during this intervention period. Body composition, total energy intake, and training time of the participants revealed no significant changes during the intervention period. The occupation ratio of spp. was significantly increased at 3 and 4 weeks (18.0 ± 8.3% and 17.6 ± 8.5%, respectively) compared to that of pre-intervention (11.7 ± 7.3%) ( = 0.019 and = 0.035, respectively). The serum TRACP-5b level was significantly decreased at 12 weeks (363 ± 112 mU/dL) compared to that at baseline (430 ± 154 mU/dL) ( = 0.018). These results suggest that the prebiotic food used in this study might have beneficial effects on bone health and gut microbial environment among female athletes. Further studies are warranted to identify the mechanism of the prebiotics-gut-bone axis.

Citing Articles

Fueling Gut Microbes: A Review of the Interaction between Diet, Exercise, and the Gut Microbiota in Athletes.

Hughes R, Holscher H Adv Nutr. 2021; 12(6):2190-2215.

PMID: 34229348 PMC: 8634498. DOI: 10.1093/advances/nmab077.

References

Whisner C, Castillo L . Prebiotics, Bone and Mineral Metabolism. Calcif Tissue Int. 2017; 102(4):443-479. PMC: 5851694. DOI: 10.1007/s00223-017-0339-3. View

Kruger M, Chan Y, Kuhn-Sherlock B, Lau L, Lau C, Chin Y . Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women. Eur J Nutr. 2015; 55(5):1911-21. DOI: 10.1007/s00394-015-1007-x. View

Coudray C, Tressol J, Gueux E, Rayssiguier Y . Effects of inulin-type fructans of different chain length and type of branching on intestinal absorption and balance of calcium and magnesium in rats. Eur J Nutr. 2003; 42(2):91-8. DOI: 10.1007/s00394-003-0390-x. View

Sakai Y, Seki N, Hamano K, Ochi H, Abe F, Masuda K . Prebiotic effect of two grams of lactulose in healthy Japanese women: a randomised, double-blind, placebo-controlled crossover trial. Benef Microbes. 2019; 10(6):629-639. DOI: 10.3920/BM2018.0174. View

Pepper M, Akuthota V, McCarty E . The pathophysiology of stress fractures. Clin Sports Med. 2005; 25(1):1-16, vii. DOI: 10.1016/j.csm.2005.08.010. View

Barrack M, Gibbs J, De Souza M, Williams N, Nichols J, Rauh M . Higher incidence of bone stress injuries with increasing female athlete triad-related risk factors: a prospective multisite study of exercising girls and women. Am J Sports Med. 2014; 42(4):949-58. DOI: 10.1177/0363546513520295. View

Markowiak-Kopec P, Slizewska K . The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients. 2020; 12(4). PMC: 7230973. DOI: 10.3390/nu12041107. View

Gibson G, Hutkins R, Sanders M, Prescott S, Reimer R, Salminen S . Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017; 14(8):491-502. DOI: 10.1038/nrgastro.2017.75. View

Cialdella-Kam L, Guebels C, Maddalozzo G, Manore M . Dietary intervention restored menses in female athletes with exercise-associated menstrual dysfunction with limited impact on bone and muscle health. Nutrients. 2014; 6(8):3018-39. PMC: 4145292. DOI: 10.3390/nu6083018. View

10.

Zimmermann M, Chassard C, Rohner F, NGoran E, Nindjin C, Dostal A . The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire. Am J Clin Nutr. 2010; 92(6):1406-15. DOI: 10.3945/ajcn.110.004564. View

11.

Lucas S, Omata Y, Hofmann J, Bottcher M, Iljazovic A, Sarter K . Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 2018; 9(1):55. PMC: 5754356. DOI: 10.1038/s41467-017-02490-4. View

12.

Sakai Y, Seki N, Hamano H, Ochi H, Abe F, Shimizu F . A study of the prebiotic effect of lactulose at low dosages in healthy Japanese women. Biosci Microbiota Food Health. 2019; 38(2):69-72. PMC: 6502711. DOI: 10.12938/bmfh.18-013. View

13.

Ihle R, Loucks A . Dose-response relationships between energy availability and bone turnover in young exercising women. J Bone Miner Res. 2004; 19(8):1231-40. DOI: 10.1359/JBMR.040410. View

14.

Barrack M, Van Loan M, Rauh M, Nichols J . Physiologic and behavioral indicators of energy deficiency in female adolescent runners with elevated bone turnover. Am J Clin Nutr. 2010; 92(3):652-9. DOI: 10.3945/ajcn.2009.28926. View

15.

Nattiv A, Loucks A, Manore M, Sanborn C, Sundgot-Borgen J, Warren M . American College of Sports Medicine position stand. The female athlete triad. Med Sci Sports Exerc. 2007; 39(10):1867-82. DOI: 10.1249/mss.0b013e318149f111. View

16.

Parvaneh K, Ebrahimi M, Sabran M, Karimi G, Hwei A, Abdul-Majeed S . Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy. Biomed Res Int. 2015; 2015:897639. PMC: 4558422. DOI: 10.1155/2015/897639. View

17.

Yamada S, Inaba M, Kurajoh M, Shidara K, Imanishi Y, Ishimura E . Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction. Clin Endocrinol (Oxf). 2008; 69(2):189-96. DOI: 10.1111/j.1365-2265.2008.03187.x. View

18.

Mallinson R, Williams N, Olmsted M, Scheid J, Riddle E, De Souza M . A case report of recovery of menstrual function following a nutritional intervention in two exercising women with amenorrhea of varying duration. J Int Soc Sports Nutr. 2013; 10:34. PMC: 3750722. DOI: 10.1186/1550-2783-10-34. View

19.

Sundgot-Borgen J, Meyer N, Lohman T, Ackland T, Maughan R, Stewart A . How to minimise the health risks to athletes who compete in weight-sensitive sports review and position statement on behalf of the Ad Hoc Research Working Group on Body Composition, Health and Performance, under the auspices of the IOC Medical.... Br J Sports Med. 2013; 47(16):1012-22. DOI: 10.1136/bjsports-2013-092966. View

20.

Ishizu T, Torii S, Taguchi M . Habitual Dietary Status and Stress Fracture Risk Among Japanese Female Collegiate Athletes. J Am Nutr Assoc. 2021; 41(5):481-488. DOI: 10.1080/07315724.2021.1920068. View