Sequential Drug Delivery to Modulate Macrophage Behavior and Enhance Implant Integration

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2019 May 20

PMID 31103451

Citations 39

Authors

Erin M OBrien

Gregory E Risser

Kara L Spiller

Affiliations

Soon will be listed here.

Abstract

Macrophages are major upstream regulators of the inflammatory response to implanted biomaterials. Sequential functions of distinct macrophage phenotypes are essential to the normal tissue repair process, which ideally results in vascularization and integration of implants. Improper timing of M1 or M2 macrophage activation results in dysfunctional healing in the form of chronic inflammation or fibrous encapsulation of the implant. Thus, biphasic drug delivery systems that modulate macrophage behavior are an appealing approach to promoting implant integration. In this review, we describe the timing and roles of macrophage phenotypes in healing, then highlight current drug delivery systems designed to sequentially modulate macrophage behavior.

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