Density of Surface Immunoglobulin and Capping on Rat B Lymphocytes. I. Changes with Aging

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1979 Feb 1

PMID 310864

Citations 8

Authors

B A Woda

J D FELDMAN

Affiliations

Soon will be listed here.

Abstract

The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with a high density of SIg. Cells with the highest density of SIg capped and shed cross-linked SIg faster than cells with a low density of SIg. The alteration in density of SIg may account for the difference in capping kinetics. Colchicine treatment increased the rate of capping of lymphocytes from young animals, but had no effect on the capping kinetics of lymphocytes from old animals.

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References

Kay M . Effect of age on T cell differentiation. Fed Proc. 1978; 37(5):1241-4. View

Gabbiani G, Chaponnier C, Zumbe A, Vassalli P . Actin and tubulin co-cap with surface immunoglobulins in mouse B lymphocytes. Nature. 1977; 269(5630):697-8. DOI: 10.1038/269697a0. View

Yakara I . Microtubule organization of lymphocytes and its modulation by patch and cap formation. Cell. 1978; 15(1):251-9. DOI: 10.1016/0092-8674(78)90100-9. View

Singhal S, Roder J, Duwe A . Suppressor cells in immunosenescence. Fed Proc. 1978; 37(5):1245-52. View

Schreiner G, Fujiwara K, Pollard T, UNANUE E . Redistribution of myosin accompanying capping of surface Ig. J Exp Med. 1977; 145(5):1393-8. PMC: 2180660. DOI: 10.1084/jem.145.5.1393. View

Ault K, UNANUE E . Failure of B lymphocytes in human blood to regenerate surface immunoglobulin after its removal by antibody. J Immunol. 1977; 119(1):327-9. View

van Blitterswijk W, Emmelot P, Hilkmann H, Oomenmeulemans E, Inbar M . Differences in lipid fluidity among isolated plasma membranes of normal and leukemic lympocytes and membranes exfoliated from their cell surface. Biochim Biophys Acta. 1977; 467(3):309-20. DOI: 10.1016/0005-2736(77)90308-x. View

Fram R, Sidman C, UNANUE E . Genetic control of ligand-induced events in B lymphocytes. J Immunol. 1976; 117(5 Pt 1):1456-63. View

Antoine J, Avrameas S . Surface immunoglobulins of rat immunocytes: quantitation and fate of cell-bound peroxidase-labeled antibody and Fab fragment. Eur J Immunol. 1974; 4(7):468-74. DOI: 10.1002/eji.1830040705. View

10.

OSMOND D, Nossal G . Differentiation of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling. Cell Immunol. 1974; 13(1):132-45. DOI: 10.1016/0008-8749(74)90233-0. View

11.

Loken M, Herzenber L . Analysis of cell populations with a fluorescence-activated cell sorter. Ann N Y Acad Sci. 1975; 254:163-71. DOI: 10.1111/j.1749-6632.1975.tb29166.x. View

12.

Heidrick M, Makinodan T . Nature of cellular dificiencies in age-related decline of the immune system. Gerontologia. 1972; 18(5-6):305-20. DOI: 10.1159/000211942. View

13.

Price G, Makinodan T . Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies. J Immunol. 1972; 108(2):403-12. View

14.

SCHER I, Sharrow S, WISTAR Jr R, Asofsky R, Paul W . B-lymphocyte heterogeneity: ontogenetic development and organ distribution of B-lymphocyte populations defined by their density of surface immunoglobulin. J Exp Med. 1976; 144(2):494-506. PMC: 2190375. DOI: 10.1084/jem.144.2.494. View

15.

Sidman C, UNANUE E . Development of B lymphocytes. I. Cell populations and a critical event during ontogeny. J Immunol. 1975; 114(6):1730-5. View