Time Course Observation of Outcomes Between Minimally Invasive Transforaminal Lumbar Interbody Fusion and Posterior Lumbar Interbody Fusion

The purpose of this study is to compare the long-term patient-outcomes, spinal fusion, and incidence of adjacent segment degeneration (ASD) between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and open posterior lumbar interbody fusion (O-PLIF). We retrospectively reviewed 70 consecutive cases who underwent single-level MIS-TLIF or O-PLIF from March 2010 to July 2013. All the patients achieved a minimum of 5-year follow-up. Data collected for each patient included demographic data, perioperative data, and complications. Clinical outcomes were evaluated with Oswestry disability index and visual analogue scale (VAS). Radiological outcomes included fusion rate and ASD. About 34 patients of MIS-TLIF and 36 patients of O-PLIF were enrolled. Higher Charlson comorbidity index scores were noted in MIS-TLIF than in O-PLIF. Blood loss was significantly lower in MIS-TLIF than O-PLIF. There were significant improvements in clinical and radiological outcomes in both groups. At 6 months, in MIS-TLIF group had significantly lower VAS for back pain and disc height compared with in O-PLIF group. The fusion rate was similar between the two groups at 5-year follow-up. Although the total complication rates were similar between the two groups, both the incidence of ASD was significantly higher in O-PLIF group than MIS-TLIF group (P = 0.032). In conclusion, this study indicates that MIS-TLIF is comparable to O-PLIF in terms of fusion rates and clinical outcomes in single-segment degenerative lumbar diseases. In addition, compared with O-PLIF, MIS-TLIF has the advantages of lesser blood loss, faster recovery, and lower incidence of ASD.