Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis

Overview

Journal Synlett

Specialty Chemistry

Date 2019 Apr 30

PMID 31031546

Citations 12

Authors

Bradley S Moore

Affiliations

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Abstract

Meroterpenoid natural products are important bioactive molecules with broad distribution throughout nature. In bacteria, naphthoquinone-based meroterpenoids comprise a simple yet structurally fascinating group of natural product antibiotics that are enzymatically constructed through a series of asymmetric alkene and arene halofunctionalization reactions. This account article highlights our discovery and characterization of a group of vanadium-dependent chloroperoxidase enzymes that catalyze halogen-assisted cyclization and rearrangement reactions and have inspired biomimetic syntheses of numerous meroterpenoid natural products.

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