Biosynthesis of Napyradiomycins

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1987 Dec 1

PMID 3429338

Citations 15

Authors

K Shiomi

H Iinuma

H Naganawa

K Isshiki

T Takeuchi

H Umezawa

Affiliations

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Abstract

Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.

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