Disulfide-Catalyzed Iodination of Electron-Rich Aromatic Compounds

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2019 Apr 26

PMID 31021625

Citations 6

Authors

Keisuke Iida

Shunsuke Ishida

Takamichi Watanabe

Takayoshi Arai

Affiliations

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Abstract

Herein, a disulfide-catalyzed electrophilic iodination of aromatic compounds using 1,3-diiodo-5,5-dimethylhydantoin (DIH) has been developed. The disulfide activates DIH as a Lewis base to promote the iodination reaction in acetonitrile under mild conditions. This system is applicable to a wide range of electron-rich aromatic compounds, including acetanilide, anisole, imidazole, and pyrazole derivatives.

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