Takayoshi Arai

By replacing a carbon atom of boranils with a nitrogen atom, azaboranils were newly designed. In the 2'-azaboranils synthesized from 2-aminopyridines with 2-hydroxy-1-naphthaldehyde, the pyridine ring underwent a hydrogen-bonding interaction...

A newly developed -9-anthranylmethyl bis(imidazolidine)pyridine (-9-Anth-PyBidine)-Cu(OAc) complex catalyzed asymmetric haloimidation reactions of alkylidenemalononitriles with -bromosuccinimide and -chlorosuccinimide, employing the succinimide moiety directly as a copper-bound nucleophile. The anthranyl substituent showed...

A bis(imidazolidine)-derived NCN nickel-pincer complex (Bu-PhBidine-Ni-OTf: ) was synthesized by the oxidative addition of imidazolidine-containing aryl triflate to Ni(cod) in MeCN. exhibited asymmetric induction in three reactions. In the Friedel-Crafts...

Background/aim: MHC-class I-related chain A (MICA) functions as a ligand for natural killer group D, an activating receptor on natural killer (NK) cells, and its expression correlates with the carcinogenesis...

A chiral imidazolidine-containing NCN-pincer Pd-OTf complex () promoted the asymmetric nucleophilic addition of unprotected 2-vinylindoles to -Boc imines in a Friedel-Crafts-type manner. The chiral (2-vinyl-1-indol-3-yl)methanamine products become nice platforms for...

G-quadruplexes (G4s) regulate various biological processes in cells. However, cellular imaging of dynamically forming G4s in biomolecular condensates using small molecules has been poorly investigated. Herein, we present a fluorescent...

A newly prepared trinuclear Zn-(,,)-aminoiminobinaphthoxide complex () catalyzed the first general intermolecular asymmetric iodoetherification of unfunctionalized alkenes. Using , the iodoetherification reaction of unfunctionalized alkenes with -nitrophenols proceeded smoothly to...

A chiral quinine-derived organic base catalyst with halogen bond donor functionality was used to catalyze the asymmetric double Mannich reaction of malononitrile with N-Boc and N-Cbz imines to afford 1,3-diamines...

A stable, hypervalent cyclic dibenzoiodolium salt acted as a strong halogen bonding (XB)-donor catalyst for [4+2] cycloaddition of 2-alkenylindoles, and not as an oxidizing agent. The cross-[4+2] cycloaddition of 2-vinylindoles...

Chiral -symmetric 3,3'-bis(()-2-naphthylethylaminomethyl)-()-binaphthol () functions as an efficient organocatalyst for the asymmetric epoxidation of various alkylidenemalononitriles. The spiro-epoxyoxindole products obtained from isatilidenemalononitriles were easily transformed to the corresponding chiral dihydroquinoxalinyl...