Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate

Overview

Journal Adv Pharm Bull

Date 2019 Apr 24

PMID 31011564

Citations 6

Authors

Mostafa Mabrouk

Sayed Hamed Kenawy

Gehan El-Tabie El-Bassyouni

Ahmed Abd El-Fattah Ibrahim Soliman

Esmat Mahmoud Aly Hamzawy

Affiliations

Soon will be listed here.

Abstract

Different compositions of copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and cytotoxicity was investigated. The microcrystalline structure revealed the decrement of the size from (20-36 nm) to (5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycycline hyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusion of CuO and Dox didn't show any remarkable changes on the physicochemical properties of the CuO-doped calcium silicate nanoparticles. The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicity against the tested cell lines compared to the CuO-free sample. CuO-doped materials displayed significant anticancer effect; this sheds light on its implication in the treatment of cancer.

Citing Articles

Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer.

Sarma K, Akther M, Ahmad I, Afzal O, Altamimi A, Alossaimi M Molecules. 2024; 29(5).

PMID: 38474590 PMC: 10934468. DOI: 10.3390/molecules29051076.

CuO nanoparticles for green synthesis of significant anti-Helicobacter pylori compounds with in silico studies.

Shehab W, Elsayed D, Abdel Hamid A, Assy M, Mouneir S, Hamed E Sci Rep. 2024; 14(1):1608.

PMID: 38238369 PMC: 10796945. DOI: 10.1038/s41598-024-51708-1.

Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice.

ElShebiney S, Elgohary R, Kenawy S, El-Bassyouni G, Hamzawy E BMC Pharmacol Toxicol. 2023; 24(1):9.

PMID: 36759887 PMC: 9912638. DOI: 10.1186/s40360-023-00647-0.

Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy.

Al Bostami R, Abuwatfa W, Husseini G Nanomaterials (Basel). 2022; 12(15).

PMID: 35957103 PMC: 9370272. DOI: 10.3390/nano12152672.

A Novel Treatment of Schistosomiasis: Nano-Calcium Silicate Incorporating 5% Copper Oxide.

Abou El-Nour M, Kenawy S, El-Bassyouni G, Hamzawy E Adv Pharm Bull. 2021; 11(1):68-76.

PMID: 33747853 PMC: 7961221. DOI: 10.34172/apb.2021.004.

References

Thabrew M, Hughes R, McFarlane I . Screening of hepatoprotective plant components using a HepG2 cell cytotoxicity assay. J Pharm Pharmacol. 1997; 49(11):1132-5. DOI: 10.1111/j.2042-7158.1997.tb06055.x. View

Costa P, Sousa Lobo J . Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001; 13(2):123-33. DOI: 10.1016/s0928-0987(01)00095-1. View

Dornbusch K . The detection of doxycycline activity in human bone. Scand J Infect Dis Suppl. 1976; (9):47-53. View

Gnarpe H, Dornbusch K, Hagg O . Doxycycline concentration levels in bone, soft tissue and serum after intravenous infusion of doxycycline. A clinical study. Scand J Infect Dis Suppl. 1976; (9):54-7. View

Mabrouk M, Choonara Y, Kumar P, du Toit L, Pillay V . The Influence of Lyophilized EmuGel Silica Microspheres on the Physicomechanical Properties, In Vitro Bioactivity and Biodegradation of a Novel Ciprofloxacin-Loaded PCL/PAA Scaffold. Polymers (Basel). 2019; 8(6). PMC: 6432423. DOI: 10.3390/polym8060232. View

Spellberg B, Lipsky B . Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis. 2011; 54(3):393-407. PMC: 3491855. DOI: 10.1093/cid/cir842. View

Kalaivani S, Singh R, Ganesan V, Kannan S . Effect of copper (Cu) inclusion on the bioactivity and antibacterial behavior of calcium silicate coatings on titanium metal. J Mater Chem B. 2020; 2(7):846-858. DOI: 10.1039/c3tb21522a. View

El-Menshawi B, Fayad W, Mahmoud K, El-Hallouty S, El-Manawaty M, Olofsson M . Screening of natural products for therapeutic activity against solid tumors. Indian J Exp Biol. 2010; 48(3):258-64. View

Denoyer D, Masaldan S, La Fontaine S, Cater M . Targeting copper in cancer therapy: 'Copper That Cancer'. Metallomics. 2015; 7(11):1459-76. DOI: 10.1039/c5mt00149h. View

10.

Phaechamud T, Chanyaboonsub N, Setthajindalert O . Doxycycline hyclate-loaded bleached shellac in situ forming microparticle for intraperiodontal pocket local delivery. Eur J Pharm Sci. 2016; 93:360-70. DOI: 10.1016/j.ejps.2016.08.034. View

11.

Zhang H, Ye X, Li J . Preparation and biocompatibility evaluation of apatite/wollastonite-derived porous bioactive glass ceramic scaffolds. Biomed Mater. 2009; 4(4):045007. DOI: 10.1088/1748-6041/4/4/045007. View

12.

Oh S, Nam B, Lee I, Lee J . Prolonged anti-bacterial activity of ion-complexed doxycycline for the treatment of osteomyelitis. Eur J Pharm Biopharm. 2015; 98:67-75. DOI: 10.1016/j.ejpb.2015.11.006. View

13.

Wu C, Fan W, Zhu Y, Gelinsky M, Chang J, Cuniberti G . Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure. Acta Biomater. 2011; 7(10):3563-72. DOI: 10.1016/j.actbio.2011.06.028. View

14.

Tsigkou O, Labbaf S, Stevens M, Porter A, Jones J . Monodispersed bioactive glass submicron particles and their effect on bone marrow and adipose tissue-derived stem cells. Adv Healthc Mater. 2013; 3(1):115-25. DOI: 10.1002/adhm.201300126. View

15.

Mabrouk M, Choonara Y, Marimuthu T, Kumar P, du Toit L, van Vuuren S . Ca3(PO4)2 precipitated layering of an in situ hybridized PVA/Ca2O4Si nanofibrous antibacterial wound dressing. Int J Pharm. 2016; 507(1-2):41-9. DOI: 10.1016/j.ijpharm.2016.05.011. View

16.

Jany T, Moreth A, Gruschka C, Sischka A, Spiering A, Dieding M . Rational design of a cytotoxic dinuclear Cu2 complex that binds by molecular recognition at two neighboring phosphates of the DNA backbone. Inorg Chem. 2015; 54(6):2679-90. DOI: 10.1021/ic5028465. View

17.

Jose G, Santra S, Mandal S, Sengupta T . Singlet oxygen mediated DNA degradation by copper nanoparticles: potential towards cytotoxic effect on cancer cells. J Nanobiotechnology. 2011; 9:9. PMC: 3072310. DOI: 10.1186/1477-3155-9-9. View

18.

Dasari S, Tchounwou P . Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014; 740:364-78. PMC: 4146684. DOI: 10.1016/j.ejphar.2014.07.025. View

19.

Lu H, Zhang T, Wang X, Fang Q . Electrospun submicron bioactive glass fibers for bone tissue scaffold. J Mater Sci Mater Med. 2008; 20(3):793-8. DOI: 10.1007/s10856-008-3649-1. View