Long Noncoding RNA LINC00341 Promotes the Vascular Smooth Muscle Cells Proliferation and Migration Via MiR-214/FOXO4 Feedback Loop

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2019 Apr 12

PMID 30972207

Citations 12

Authors

Xiu Liu

Bing-Dong Ma

Shan Liu

Ju Liu

Bao-Xin Ma

Affiliations

Soon will be listed here.

Abstract

Increasing evidences have indicated the vital roles of long noncoding RNA (lncRNA) in the atherosclerosis. However, whether lncRNA LINC00341 play pivotal roles in the vascular smooth muscle cells (VSMCs) is still unclear. This work presents the authentic functions of LINC00341 on the proliferation and migration of VSMCs and unveils the underlying mechanism. Functional experiment data demonstrated that LINC00341 expression was increased in the ox-LDL induced VSMCs with dose-dependent and time-dependent mode. Moreover, the knockdown of LINC00341 suppressed the proliferation and migration ability of VSMCs. Mechanically, we found that LINC00341 promoted the FOXO4 protein expression via sponging miR-214, which, in return, resulting in the transcription activation of LINC00341. In conclusion, the results conclude that LINC00341 promotes the proliferation and migration of VSMCs and confirm the positive feedback loop of LINC00341/miR-214/FOXO4 axis.

Citing Articles

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