The Role of Monocytosis and Neutrophilia in Atherosclerosis

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Jan 25

PMID 29364567

Citations 35

Authors

Dimitry A Chistiakov

Andrey V Grechko

Veronika A Myasoedova

Alexandra A Melnichenko

Alexander N Orekhov

Affiliations

Soon will be listed here.

Abstract

Monocytosis and neutrophilia are frequent events in atherosclerosis. These phenomena arise from the increased proliferation of hematopoietic stem and multipotential progenitor cells (HSPCs) and HSPC mobilization from the bone marrow to other immune organs and circulation. High cholesterol and inflammatory signals promote HSPC proliferation and preferential differentiation to the myeloid precursors (i.e., myelopoiesis) that than give rise to pro-inflammatory immune cells. These cells accumulate in the plaques thereby enhancing vascular inflammation and contributing to further lesion progression. Studies in animal models of atherosclerosis showed that manipulation with HSPC proliferation and differentiation through the activation of LXR-dependent mechanisms and restoration of cholesterol efflux may have a significant therapeutic potential.

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