Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2019 Apr 4

PMID 30941103

Citations 9

Authors

Maurizio Poli

Laura Girardi

Marco Fabiani

Martina Moretto

Valeria Romanelli

Cristina Patassini

Daniela Zuccarello

Antonio Capalbo

Affiliations

Soon will be listed here.

Abstract

Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and polygenic conditions. Diagnostic expansion into epigenetic and transcriptomic assessment in the near future are potential technological targets which may improve the prognostic outlook of patients of advanced reproductive age and overall fertilization (IVF) treatment outcomes. In this review, we discuss the technological progress of recent years and their future applications in preimplantation genetic testing in IVF.

Citing Articles

Uniparental disomy (UPD) exclusion in embryos following Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR).

Fabiani M, Margiotti K, Libotte F, Ali C, Zangheri C, Barone M J Assist Reprod Genet. 2024; 42(1):265-273.

PMID: 39693035 PMC: 11805737. DOI: 10.1007/s10815-024-03352-x.

Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.

Capalbo A, de Wert G, Mertes H, Klausner L, Coonen E, Spinella F Hum Reprod Update. 2024; 30(5):529-557.

PMID: 38805697 PMC: 11369226. DOI: 10.1093/humupd/dmae012.

Preimplantation genetic testing for embryos predisposed to hereditary cancer: Possibilities and challenges.

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Genetic counseling for pre-implantation genetic testing of monogenic disorders (PGT-M).

Parikh F, Athalye A, Madon P, Khandeparkar M, Naik D, Sanap R Front Reprod Health. 2024; 5:1213546.

PMID: 38162012 PMC: 10755023. DOI: 10.3389/frph.2023.1213546.

Effectiveness of non-invasive chromosomal screening for normal karyotype and chromosomal rearrangements.

Sun B, Wang Y, Sixi-Wen , Zhou L, Zhang C, Wu Z Front Genet. 2023; 14:1036467.

PMID: 36992701 PMC: 10040604. DOI: 10.3389/fgene.2023.1036467.

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