Gender and Survival of Critically Ill Patients: Results from the FROG-ICU Study

Overview

Journal Ann Intensive Care

Specialty Critical Care

Date 2019 Mar 31

PMID 30927096

Citations 18

Authors

Alexa Hollinger

Etienne Gayat

Elodie Feliot

Catherine Paugam-Burtz

Marie-Celine Fournier

Jacques Duranteau

Jean-Yves Lefrant

Marc Leone

Samir Jaber

Alexandre Mebazaa

Mattia Arrigo

Affiliations

Soon will be listed here.

Abstract

Purpose: Few studies analyzed gender-related outcome differences of critically ill patients and found inconsistent results. This study aimed to test the independent association of gender and long-term survival of ICU patients.

Materials And Methods: FROG-ICU was a prospective, observational, multi-center cohort designed to investigate the long-term mortality of critically ill adult patients. The primary endpoint of this study was 1-year mortality after ICU admission of women compared to men.

Results: The study included 2087 patients, 726 women and 1361 men. Women and men had similar baseline characteristics, clinical presentation, and disease severity. No significant difference in 1-year mortality was found between women and men (34.9% vs. 37.9%, P = 0.18). After multivariable adjustment, no difference in the hazard of death was observed [HR 0.99 (95% CI 0.77-1.28)]. Similar 1-year survival between women and men was found in a propensity score-matched patient cohort of 506 patients [HR 0.79 (95% CI 0.54-1.14)].

Conclusion: Women constituted one-third of the population of critically ill patients and were unexpectedly similar to men regarding demographic characteristics, clinical presentation, and disease severity and had similar risk of death at 1 year after ICU admission. Trial registration ClinicalTrials.gov NCT01367093; registered on June 6, 2011.

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