Diastereo- and Enantioselective Access to Stereotriads Through a Flexible Coupling of Substituted Aldehydes and Alkenes

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2019 Mar 29

PMID 30919530

Citations 3

Authors

Jing Li

Alexander Preinfalk

Nuno Maulide

Affiliations

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Abstract

A flexible redox-neutral coupling of aldehydes and alkenes enables rapid access to stereotriads starting from a single stereocenter with perfect levels of enantio- and diastereoselectivity under mild conditions. The versatility of the method is highlighted by the installation of heteroatoms along the tether, which enables a route to structurally diverse building blocks. The formal synthesis of (+)-neopeltolide further demonstrates the synthetic utility of this approach.

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Diastereo- and Enantioselective Access to Stereotriads through a Flexible Coupling of Substituted Aldehydes and Alkenes.

Li J, Preinfalk A, Maulide N Angew Chem Int Ed Engl. 2019; 58(18):5887-5890.

PMID: 30919530 PMC: 6492014. DOI: 10.1002/anie.201900801.

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