Neutrophils As Regulators of the Hematopoietic Niche

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2019 Mar 23

PMID 30898859

Citations 29

Authors

Itziar Cossio

Daniel Lucas

Andres Hidalgo

Affiliations

Soon will be listed here.

Abstract

The niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation in response to changing physiological demands or pathological insults. The dynamic and environment-sensing properties of the niche are shared by the innate immune system. Thus, it is not surprising that innate immune cells, including macrophages and neutrophils, are now recognized as important regulators of the hematopoietic niche and, ultimately, of the stem cells from which they derive. This review synthesizes emerging concepts on niche regulation by immune cells, with a particular emphasis on neutrophils. We argue that the unique developmental, circadian, and migratory properties of neutrophils underlie their critical contributions as regulators of the hematopoietic niche.

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