Rhythmic Modulation of the Hematopoietic Niche Through Neutrophil Clearance

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2013 May 28

PMID 23706740

Citations 370

Authors

Maria Casanova-Acebes

Christophe Pitaval

Linnea A Weiss

Cesar Nombela-Arrieta

Raphael Chevre

Noelia A-Gonzalez

Yuya Kunisaki

Dachuan Zhang

Nico van Rooijen

Leslie E Silberstein

Christian Weber

Takashi Nagasawa

Paul S Frenette

Antonio Castrillo

Andres Hidalgo

Affiliations

Soon will be listed here.

Abstract

Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the homeostatic clearance of neutrophils provides cues that modulate the physiology of the bone marrow. We identify a population of CD62L(LO) CXCR4(HI) neutrophils that have "aged" in the circulation and are eliminated at the end of the resting period in mice. Aged neutrophils infiltrate the bone marrow and promote reductions in the size and function of the hematopoietic niche. Modulation of the niche depends on macrophages and activation of cholesterol-sensing nuclear receptors and is essential for the rhythmic egress of hematopoietic progenitors into the circulation. Our results unveil a process that synchronizes immune and hematopoietic rhythms and expand the ascribed functions of neutrophils beyond inflammation. PAPERFLICK:

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