Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2019 Mar 21

PMID 30893588

Citations 77

Authors

Anubhav N Mathur

Bahar Zirak

Ian C Boothby

Madge Tan

Jarish N Cohen

Thea M Mauro

Pooja Mehta

Margaret M Lowe

Abul K Abbas

Niwa Ali

Michael D Rosenblum

Affiliations

Soon will be listed here.

Abstract

Restoration of barrier-tissue integrity after injury is dependent on the function of immune cells and stem cells (SCs) residing in the tissue. In response to skin injury, hair-follicle stem cells (HFSCs), normally poised for hair generation, are recruited to the site of injury and differentiate into cells that repair damaged epithelium. We used a SC fate-mapping approach to examine the contribution of regulatory T (Treg) cells to epidermal-barrier repair after injury. Depletion of Treg cells impaired skin-barrier regeneration and was associated with a Th17 inflammatory response and failed HFSC differentiation. In this setting, damaged epithelial cells preferentially expressed the neutrophil chemoattractant CXCL5, and blockade of CXCL5 or neutrophil depletion restored barrier function and SC differentiation after epidermal injury. Thus, Treg-cell regulation of localized inflammation enables HFSC differentiation and, thereby, skin-barrier regeneration, with implications for the maintenance and repair of other barrier tissues.

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