A Review of MicroRNA Biomarkers in Traumatic Brain Injury

Overview

Journal J Exp Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2019 Mar 20

PMID 30886525

Citations 71

Authors

Hamna Atif

Steven D Hicks

Affiliations

Soon will be listed here.

Abstract

There is growing public concern surrounding traumatic brain injury (TBI). TBI can cause significant morbidity, and the long-term sequelae are poorly understood. TBI diagnosis and management rely on patient-reported symptoms and subjective clinical assessment. There are no biologic tools to detect mild TBI or to track brain recovery. Emerging evidence suggests that microRNAs (miRNAs) may provide information about the injured brain. These tiny epigenetic molecules are expressed throughout the body. However, they are particularly important in neurons, can cross the blood-brain barrier, and are securely transported from cell to cell, where they regulate gene expression. miRNA levels may identify patients with TBI and predict symptom duration. This review synthesizes miRNA findings from 14 human studies. We distill more than 291 miRNAs to 17 biomarker candidates that overlap across multiple studies and multiple biofluids. The goal of this review is to establish a collective understanding of miRNA biology in TBI and identify clinical priorities for future investigations of this promising biomarker.

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References

Bazarian J, Wong T, Harris M, Leahey N, Mookerjee S, Dombovy M . Epidemiology and predictors of post-concussive syndrome after minor head injury in an emergency population. Brain Inj. 1999; 13(3):173-89. DOI: 10.1080/026990599121692. View

Howell B, Herrick T, Cooper J . Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning. Genes Dev. 1999; 13(6):643-8. PMC: 316552. DOI: 10.1101/gad.13.6.643. View

Tyler B, Jansen K, McCormick D, Douglas C, Boules M, Stewart J . Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression. Proc Natl Acad Sci U S A. 1999; 96(12):7053-8. PMC: 22053. DOI: 10.1073/pnas.96.12.7053. View

Cano A, Perez-Moreno M, Rodrigo I, Locascio A, Blanco M, del Barrio M . The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2000; 2(2):76-83. DOI: 10.1038/35000025. View

Fatemi S, Earle J, McMenomy T . Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry. 2000; 5(6):654-63, 571. DOI: 10.1038/sj.mp.4000783. View

Lau L, Yu A . Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. J Neurotrauma. 2001; 18(3):351-9. DOI: 10.1089/08977150151071035. View

Bazarian J, Atabaki S . Predicting postconcussion syndrome after minor traumatic brain injury. Acad Emerg Med. 2001; 8(8):788-95. DOI: 10.1111/j.1553-2712.2001.tb00208.x. View

de Kruijk J, Leffers P, Menheere P, Meerhoff S, Rutten J, Twijnstra A . Prediction of post-traumatic complaints after mild traumatic brain injury: early symptoms and biochemical markers. J Neurol Neurosurg Psychiatry. 2002; 73(6):727-32. PMC: 1757354. DOI: 10.1136/jnnp.73.6.727. View

Nelson P, Kiriakidou M, Sharma A, Maniataki E, Mourelatos Z . The microRNA world: small is mighty. Trends Biochem Sci. 2003; 28(10):534-40. DOI: 10.1016/j.tibs.2003.08.005. View

10.

Chen C, Li L, Lodish H, Bartel D . MicroRNAs modulate hematopoietic lineage differentiation. Science. 2003; 303(5654):83-6. DOI: 10.1126/science.1091903. View

11.

Savaskan N, Brauer A, Nitsch R . Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Eur J Neurosci. 2004; 19(1):212-20. DOI: 10.1046/j.1460-9568.2003.03078.x. View

12.

Brennecke J, Stark A, Russell R, Cohen S . Principles of microRNA-target recognition. PLoS Biol. 2005; 3(3):e85. PMC: 1043860. DOI: 10.1371/journal.pbio.0030085. View

13.

Cheng A, Byrom M, Shelton J, Ford L . Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 2005; 33(4):1290-7. PMC: 552951. DOI: 10.1093/nar/gki200. View

14.

Cimmino A, Calin G, Fabbri M, Iorio M, Ferracin M, Shimizu M . miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005; 102(39):13944-9. PMC: 1236577. DOI: 10.1073/pnas.0506654102. View

15.

Karp X, Ambros V . Developmental biology. Encountering microRNAs in cell fate signaling. Science. 2005; 310(5752):1288-9. DOI: 10.1126/science.1121566. View

16.

Drake A, McDonald E, Magnus N, Gray N, Gottshall K . Utility of Glasgow Coma Scale-Extended in symptom prediction following mild traumatic brain injury. Brain Inj. 2006; 20(5):469-75. DOI: 10.1080/02699050600676370. View

17.

Shivdasani R . MicroRNAs: regulators of gene expression and cell differentiation. Blood. 2006; 108(12):3646-53. PMC: 1895474. DOI: 10.1182/blood-2006-01-030015. View

18.

Kalsotra A, Zhao J, Anakk S, Dash P, Strobel H . Brain trauma leads to enhanced lung inflammation and injury: evidence for role of P4504Fs in resolution. J Cereb Blood Flow Metab. 2006; 27(5):963-74. DOI: 10.1038/sj.jcbfm.9600396. View

19.

Park N, Yu T, Nabili V, Brinkman B, Henry S, Wang J . RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptome. Clin Chem. 2006; 52(12):2303-4. DOI: 10.1373/clinchem.2006.075598. View

20.

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee J, Lotvall J . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9(6):654-9. DOI: 10.1038/ncb1596. View