Efficacy of an Orally Administered Anti-diarrheal Probiotic Paste (Pro-Kolin Advanced) in Dogs with Acute Diarrhea: A Randomized, Placebo-controlled, Double-blinded Clinical Study

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2019 Mar 19

PMID 30882953

Citations 19

Authors

Sophie L Nixon

Lindsay Rose

Annika T Muller

Affiliations

Soon will be listed here.

Abstract

Background: Acute diarrhea is a common clinical presentation of dogs. The effect of specific anti-diarrheal probiotic pastes (ADPPs) in the management of acute, uncomplicated diarrhea in dogs is unknown.

Hypothesis: Administration of an ADPP containing Enterococcus faecium 4b1707 will improve the clinical outcome of acute, uncomplicated diarrhea in dogs compared to placebo.

Animals: One hundred forty-eight client-owned dogs with acute diarrhea as the main clinical sign.

Methods: Double-blinded, placebo-controlled, randomized, blocked, multicenter clinical field study conducted at 14 primary care veterinary practices in the United Kingdom and Ireland.

Results: The ADPP was associated with better clinical outcome compared to placebo in dogs with acute, uncomplicated diarrhea. Dogs in the ADPP group had a significantly shorter duration of diarrhea (ADPP: median, 32 hours; 95% confidence interval [CI], 2-118; n = 51; Placebo: median, 47 hours; 95% CI, 4-167; n = 58; P = .008) and the rate of resolution of diarrhea was 1.60 times faster in the ADPP group than in the Placebo group (ratio, 1.60; 95% CI, 1.08-2.44; P = .02). Fewer dogs required additional medical intervention (AMI) for non-improvement or worsening in the ADPP group compared to the Placebo group (3.5% of dogs and 14.8% of dogs, respectively), with a relative risk of 0.88 (P = .04; AMI, ADPP, 3.5%, 2/57 dogs; Placebo, 14.8%, 9/61 dogs; relative risk, 0.88; 95% CI, 0.77-0.99).

Conclusion And Clinical Importance: The ADPP may accelerate resolution of acute diarrhea in dogs and decrease the requirement for AMI.

Citing Articles

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