Handling History of Rats Modifies Behavioural Effects of Drugs in the Elevated Plus-maze Test of Anxiety

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1993 Apr 22

PMID 8519271

Citations 30

Authors

N Andrews

S E File

Affiliations

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Abstract

In rats naive to handling, but not in handling-habituated animals, baclofen (1 mg/kg) and (R,S) zacopride (1 microgram/kg) had significant anxiolytic effects, shown by an increased percentage of time spent on the open arms of the elevated plus-maze. The effects of buspirone were also modified by the animals' handling history and 200 micrograms/kg was significantly anxiogenic only in handling-habituated animals. The pattern of results is discussed in relation to biochemical differences already reported between handling-naive and handling-habituated animals, with particular respect to changes in the 5-HT system.

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