A New HLA-linked T Cell Membrane Molecule, Related to the Beta Chain of the Clonotypic Receptor, is Associated with T3

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1986 Aug 1

PMID 3088207

Citations 14

Authors

Y Bushkin

D N Posnett

B Pernis

C Y Wang

Affiliations

Soon will be listed here.

Abstract

The 38 kD molecule is noncovalently associated with beta 2 microglobulin (beta 2m)-free HLA heavy chain-like molecule, and thus forms a second heterodimer distinct from the clonotypic alpha/beta T cell receptor expressed by the same clone of leukemia cells. This second heterodimer (38 kD/HLA) is variably expressed and appears to be associated with the T3 molecule. We suggest, therefore, that it has a functional role in T cell activation.

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References

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

Hedrick S, Nielsen E, Kavaler J, Cohen D, Davis M . Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature. 1984; 308(5955):153-8. DOI: 10.1038/308153a0. View

Barnstable C, Bodmer W, Brown G, Galfre G, Milstein C, Williams A . Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell. 1978; 14(1):9-20. DOI: 10.1016/0092-8674(78)90296-9. View

Brodsky F, Bodmer W, Parham P . Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens. Eur J Immunol. 1979; 9(7):536-45. DOI: 10.1002/eji.1830090709. View

Krangel M, Orr H, Strominger J . Assembly and maturation of HLA-A and HLA-B antigens in vivo. Cell. 1979; 18(4):979-91. DOI: 10.1016/0092-8674(79)90210-1. View

Ploegh H, Orr H, Strominger J . Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. Cell. 1981; 24(2):287-99. DOI: 10.1016/0092-8674(81)90318-4. View

Yokoyama K, STOCKERT E, Old L, Nathenson S . Structural comparisons of TL antigens derived from normal and leukemia cells of Tl+ and TL- strains and relationship to genetically linked H-2 major histocompatibility complex products. Proc Natl Acad Sci U S A. 1981; 78(11):7078-82. PMC: 349198. DOI: 10.1073/pnas.78.11.7078. View

Hunig T, Bevan M . Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis. J Exp Med. 1982; 155(1):111-25. PMC: 2186565. DOI: 10.1084/jem.155.1.111. View

Elder J, Alexander S . endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins. Proc Natl Acad Sci U S A. 1982; 79(15):4540-4. PMC: 346710. DOI: 10.1073/pnas.79.15.4540. View

10.

Siu G, Clark S, Yoshikai Y, Malissen M, Yanagi Y, Strauss E . The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell. 1984; 37(2):393-401. DOI: 10.1016/0092-8674(84)90369-6. View

11.

Saito H, Kranz D, Takagaki Y, Hayday A, Eisen H, Tonegawa S . Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature. 1984; 309(5971):757-62. DOI: 10.1038/309757a0. View

12.

Malissen M, Minard K, Mjolsness S, Kronenberg M, Goverman J, Hunkapiller T . Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell. 1984; 37(3):1101-10. DOI: 10.1016/0092-8674(84)90444-6. View

13.

Gascoigne N, Chien Y, Becker D, Kavaler J, Davis M . Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes. Nature. 1984; 310(5976):387-91. DOI: 10.1038/310387a0. View

14.

Posnett D, Bigler R, Bushkin Y, Fisher D, Wang C, Mayer L . T cell antiidiotypic antibodies reveal differences between two human leukemias. J Exp Med. 1984; 160(2):494-505. PMC: 2187451. DOI: 10.1084/jem.160.2.494. View

15.

Siu G, Kronenberg M, Strauss E, Haars R, Mak T, Hood L . The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature. 1984; 311(5984):344-50. DOI: 10.1038/311344a0. View

16.

Rinnooy Kan E, PLATZER E, Welte K, Wang C . Modulation induction of the T3 antigen by OKT3 antibody is monocyte dependent. J Immunol. 1984; 133(6):2979-85. View

17.

Bushkin Y, Chorney M, Diamante E, Fu S, Wang C . Biochemical characterization of the human T6 antigen: a comparison between T6 and murine TL. Mol Immunol. 1984; 21(10):821-9. DOI: 10.1016/0161-5890(84)90135-4. View

18.

Sim G, Yague J, Nelson J, Marrack P, Palmer E, Augustin A . Primary structure of human T-cell receptor alpha-chain. Nature. 1984; 312(5996):771-5. DOI: 10.1038/312771a0. View

19.

Brenner M, Trowbridge I, Strominger J . Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit. Cell. 1985; 40(1):183-90. DOI: 10.1016/0092-8674(85)90321-6. View

20.

Hayday A, Saito H, Gillies S, Kranz D, Tanigawa G, Eisen H . Structure, organization, and somatic rearrangement of T cell gamma genes. Cell. 1985; 40(2):259-69. DOI: 10.1016/0092-8674(85)90140-0. View