Sequence Relationships Between Putative T-cell Receptor Polypeptides and Immunoglobulins

Overview

Journal Nature

Specialty Science

Date 1984 Mar 8

PMID 6546606

Citations 209

Authors

S M Hedrick

E A Nielsen

J Kavaler

D I Cohen

M M Davis

Affiliations

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Abstract

Comparison of the sequence of a cloned T cell-specific cDNA with those of cross-reacting cloned cDNAs isolated from a thymocyte library indicates the presence of variable, constant and joining regions remarkably similar in size and sequence to those encoding immunoglobulin proteins. Together with the evidence for somatic gene rearrangements reported in the accompanying paper, this strongly suggests that the TM86 cDNA clone encodes one chain of the T-cell receptor for antigen.

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