Listeria Monocytogenes-reactive T Lymphocyte Clones with Cytolytic Activity Against Infected Target Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1986 Jul 1

PMID 3088201

Citations 47

Authors

S H Kaufmann

E Hug

G De Libero

Affiliations

Soon will be listed here.

Abstract

Lyt-2+ T cell clones were established from Listeria monocytogenes-infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a role for specific cytotoxic T cells in the immune response to intracellular bacteria.

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