Effects of Exosomes on Pre-metastatic Niche Formation in Tumors

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2019 Mar 13

PMID 30857545

Citations 217

Authors

Yaxin Guo

Xiang Ji

Jinbo Liu

Dandan Fan

Quanbo Zhou

Chen Chen

Weiwei Wang

Guixian Wang

Haijiang Wang

Weitang Yuan

Zhenyu Ji

Zhenqiang Sun

Affiliations

Soon will be listed here.

Abstract

A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. In this review, we analyzed the effects of exosomes on pre-metastatic niches from various perspectives, including inflammation, immune response, angiogenesis, organotropism, matrix remodeling and biomarker expression. In particular, exosomes express programmed death ligand 1 (PD-L1) and cause the immune escape of tumor cells. The immunomodulatory effects of exosomes and their potential in liquid diagnosis have drawn our attention. The potential value of exosomes and pre-metastatic niches will be realized in the field of immunity therapy.

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