Genes That Mediate Breast Cancer Metastasis to Lung

Overview

Journal Nature

Specialty Science

Date 2005 Jul 29

PMID 16049480

Citations 1501

Authors

Andy J Minn

Gaorav P Gupta

Peter M Siegel

Paula D Bos

Weiping Shu

Dilip D Giri

Agnes Viale

Adam B Olshen

William L Gerald

Joan Massague

Affiliations

Soon will be listed here.

Abstract

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

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