Fc Receptor Triggering Induces Expression of Surface Activation Antigens and Release of Platelet-activating Factor in Large Granular Lymphocytes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 Apr 1

PMID 3085094

Citations 15

Authors

F Malavasi

C Tetta

A Funaro

G Bellone

E Ferrero

A C Franzone

P Dellabona

R Rusci

L Matera

G Camussi

Affiliations

Soon will be listed here.

Abstract

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

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