Release of Platelet-activating Factor (PAF) and Histamine. II. The Cellular Origin of Human PAF: Monocytes, Polymorphonuclear Neutrophils and Basophils

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1981 Feb 1

PMID 6161885

Citations 53

Authors

G Camussi

M Aglietta

R Coda

F Bussolino

W Piacibello

C Tetta

Affiliations

Soon will be listed here.

Abstract

The origin of platelet activating factor (PAF) from human leucocytes was investigated. Purified monocytes release PAF passively at pH 10.6, when challenged with Ionophore A 23187 or under phagocytic stimuli. Pure preparations of polymorphonuclear neutrophils liberate PAF passively, when challenged with C5a, neutrophil cationic proteins (CP), their carboxypeptidase B derived products (C5a des Arg, CP des Arg) or under phagocytic stimuli. Basophil rich buffy coat cells release PAF when challenged with C5a, CP, anti-IgE (in low amount) or Synacthen concomitantly with basophil degranulation and histamine release. Electron microscopy studies, carried out on Synacthen-stimulated basophil rich buffy coat, provide morphological evidence for platelet-basophil interaction. In conclusion our data demonstrate that PAF can be released from different leucocyte populations. However, the stimuli able to trigger such release appear to have some specificity for the cell target.

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